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How to Manage Small Intestine (Jejunal and Ileal) Neuroendocrine Neoplasms Presenting with Liver Metastases?

Authors
  • Niederle, Bruno1
  • Selberherr, Andreas1
  • Niederle, Martin B.1
  • 1 Medical University of Vienna, Waehringer Gürtel 18-20, Vienna, A-1090, Austria , Vienna (Austria)
Type
Published Article
Journal
Current Oncology Reports
Publisher
Springer-Verlag
Publication Date
May 20, 2021
Volume
23
Issue
7
Identifiers
DOI: 10.1007/s11912-021-01074-2
Source
Springer Nature
Keywords
License
Green

Abstract

Purpose of ReviewSmall intestinal neuroendocrine neoplasms (siNENs) are slowly growing tumours with a low malignant potential. However, more than half of the patients present with distant metastases (stage IV) and nearly all with locoregional lymph node (LN) metastases at the time of surgery. The value of locoregional treatment is discussed controversially.Recent FindingsIn stage I to III disease, locoregional surgery was currently shown to be curative prolonging survival. In stage IV disease, surgery may prolong survival in selected patients with the chance to cure locoregional disease besides radical/debulking liver surgery. It may improve the quality of life and may prevent severe local complications resulting in a state of chronic malnutrition and severe intestinal ischaemia or bowel obstruction.SummaryLocoregional tumour resection offers the opportunity to be curative or to focus therapeutically on liver metastasis, facilitating various other therapeutic modalities. Risks and benefits of the surgical intervention need to be balanced individually.

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