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How immunocompromised are short bowel patients receiving home parenteral nutrition? Apropos a case of disseminated Fusarium oxysporum sepsis.

Authors
  • Müller, Christoph
  • Schumacher, Ulrike
  • Gregor, Michael
  • Lamprecht, Georg
Type
Published Article
Journal
JPEN. Journal of parenteral and enteral nutrition
Publication Date
Jan 01, 2009
Volume
33
Issue
6
Pages
717–720
Identifiers
DOI: 10.1177/0148607109346321
PMID: 19892906
Source
Medline
License
Unknown

Abstract

(1) Catheter-related sepsis in patients on HPN is usually caused by Gram-positive or Gram-negative bacteria or by Candida species. Identification of molds in blood cultures strongly suggests Fusarium species, which should be treated appropriately with voriconazole or amphotericin B. (2) HPN and SBS aggravated by asplenism and diabetes mellitus can cause severe immunocompromise. (3) Fusaria have a strong tendency to persist or reappear after bone marrow transplantation, which is therefore relatively contraindicated in these patients.

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