Affordable Access

How does the hydrophobic content of methacrylate ABA triblock copolymers affect polymersome formation?

Authors
  • Zhang, X
  • Contini, C
  • Constantinou, A
  • Doutch, J
  • Georgiou, T
Publication Date
May 28, 2021
Source
Spiral - Imperial College Digital Repository
Keywords
License
Green
External links

Abstract

Polymersomes are exciting self-assembled structures with great potential in pharmaceutical applications. A systematic investigation of a novel series of methacrylate-based polymersomes is reported in this study. Five well-defined ABA triblock copolymers with A being based on tri(ethylene glycol) methyl methacrylate and B being based on 2-(diethylamino)ethyl methacrylate (DMAEMA) were synthesized using a living polymerization method. The effect of the composition of the ABA triblock copolymers on the thickness of the hydrophobic membrane of the polymersomes and the release of a model drug is demonstrated.

Report this publication

Statistics

Seen <100 times