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How changes in affinity of corticosteroid-binding globulin modulate free cortisol concentration.

Authors
  • Chan, Wee Lee1
  • Carrell, Robin W
  • Zhou, Aiwu
  • Read, Randy J
  • 1 Department of Hematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom. , (United Kingdom)
Type
Published Article
Journal
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Publication Date
August 2013
Volume
98
Issue
8
Pages
3315–3322
Identifiers
DOI: 10.1210/jc.2012-4280
PMID: 23783094
Source
Medline
License
Unknown

Abstract

The ability of CBG to modulate free cortisol levels in blood must be considered in the understanding and management of disease processes, as illustrated here with predictable changes in inflammation and fever.

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