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Household based-pyrethroids on adult zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions.

Authors
  • Tamagno, Wagner Antonio1
  • Alves, Carla2
  • Pompermaier, Aline3
  • Amaral, Francieli Ubirajara Índia3
  • Freddo, Natália3
  • Soares, Suelen Mendonça4
  • Gonçalves, Tayllana Schwanke5
  • Siqueira, Lisiane3
  • Fortuna, Milena4
  • Dos Santos, Hévilin Corrêa5
  • Gorrosterrazú, Amanda5
  • Reolon, Gustavo Kellermann5
  • Barcellos, Leonardo José Gil6
  • 1 Graduate Program in Pharmacology, Universidade Federal de Santa Maria, Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS 97105-900, Brazil; Biochemistry and Molecular Biology Laboratory Rosilene Rodrigues Kaizer, Federal Institute of Education, Science and Technology of Rio Grande do Sul, Campus Sertão, ERS 135, Km 25, Eng. Englert, RS 99170-000, Brazil. , (Brazil)
  • 2 Biochemistry and Molecular Biology Laboratory Rosilene Rodrigues Kaizer, Federal Institute of Education, Science and Technology of Rio Grande do Sul, Campus Sertão, ERS 135, Km 25, Eng. Englert, RS 99170-000, Brazil; Graduate Program in Bioexperimentation Universidade de Passo Fundo, BR 285, São José, Passo Fundo, RS 99052-900, Brazil. , (Brazil)
  • 3 Graduate Program in Bioexperimentation Universidade de Passo Fundo, BR 285, São José, Passo Fundo, RS 99052-900, Brazil. , (Brazil)
  • 4 Graduate Program in Pharmacology, Universidade Federal de Santa Maria, Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS 97105-900, Brazil. , (Brazil)
  • 5 Biochemistry and Molecular Biology Laboratory Rosilene Rodrigues Kaizer, Federal Institute of Education, Science and Technology of Rio Grande do Sul, Campus Sertão, ERS 135, Km 25, Eng. Englert, RS 99170-000, Brazil. , (Brazil)
  • 6 Graduate Program in Pharmacology, Universidade Federal de Santa Maria, Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS 97105-900, Brazil; Graduate Program in Bioexperimentation Universidade de Passo Fundo, BR 285, São José, Passo Fundo, RS 99052-900, Brazil. Electronic address: [email protected]. , (Brazil)
Type
Published Article
Journal
Neurotoxicology
Publication Date
May 01, 2023
Volume
96
Pages
19–27
Identifiers
DOI: 10.1016/j.neuro.2023.02.011
PMID: 36868382
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Pyrethroid-based insecticides are largely used for mosquito control. These compounds have household and agricultural applications with different formulations. Two important compounds used as household insecticides are prallethrin and transfluthrin, both from the pyrethroid chemical group. With the mode of action centered on sodium channels, pyrethroids keep the ionic sodium channels open for a long time causing the death of the insect by nervous hyperexcitability. Given the increased use of household insecticides by humans and the incidence of disease outbreaks with unknown etiology such as autism spectrum disease, schizophrenia, and Parkinson's disease we investigate some physiological inputs of these compounds on zebrafish. In this study, we evaluated the social interaction, shoaling formation, and anxiety-like behavior of zebrafish exposed chronically to transfluthrin- and prallthrin-based insecticides (T-BI and P-BI). In addition, we quantified the activity of the enzyme acetylcholinesterase (AChE) in different brain regions. We observed that both compounds caused anxiolytic behavior and reduced shoaling formation and social interaction. Their behavioral biomarkers indicated a harmful ecological effect on the specie as well as a possible impact of these compounds on autism spectrum disorder (ASD) and schizophrenia (SZP). In addition, the AChE activity would change its activity in different brain regions modulating the anxiety-like behavior and social behavior in zebrafish. We conclude that P-BI and T-BI make us alert about the relationship of these compounds with nervous diseases related to cholinergic signaling. Copyright © 2023 Elsevier B.V. All rights reserved.

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