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Host-Range Shif between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains

Authors
  • Khachou, Amira
  • Le Moullac-Vaidye, Béatrice
  • Peltier, Cécile
  • Breiman, Adrien
  • Imbert-Marcille, Berthe-Marie
  • Ruvoën-Clouet, Nathalie
  • Aouni, Mahjoub
  • Mastouri, Maha
  • Chouchane, Slaheddine
  • Le Pendu, Jacques
Publication Date
Jan 01, 2020
Source
Kaleidoscope Open Archive
Keywords
Language
English
License
Unknown
External links

Abstract

In Tunisia, we observed that rotavirus P[8]-3 and P[4] in young children with gastroenteritis associate with the secretor histo-blood-group phenotype. Inversely, the emerging P[8]-4, representing 10% of cases, was exclusively found among nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donors Secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow co-circulation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.

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