Affordable Access

deepdyve-link
Publisher Website

Host glycan utilization within the Bacteroidetes Sus-like paradigm.

Authors
  • Brown, Haley A1
  • Koropatkin, Nicole M1
  • 1 Department of Microbiology and Immunology, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA.
Type
Published Article
Journal
Glycobiology
Publisher
Oxford University Press
Publication Date
Jun 29, 2021
Volume
31
Issue
6
Pages
697–706
Identifiers
DOI: 10.1093/glycob/cwaa054
PMID: 32518945
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The Bacteroidetes are numerically abundant Gram-negative organisms of the distal human gut with a greatly expanded capacity to degrade complex glycans. A subset of these are adept at scavenging host glycans within this environment, including mucin O-linked glycans, N-linked glycoproteins and highly sulfated glycosaminoglycans (GAGs) such as heparin (Hep) and chondroitin sulfate (CS). Several recent biochemical studies have revealed the specific polysaccharide utilization loci (PULs) within the model symbiont Bacteroides thetaiotaomicron for the deconstruction of these host glycans. Here we discuss the Sus-like paradigm that defines glycan uptake by the Bacteroidetes and the salient details of the PULs that target heparin/heparan sulfate (HS) and chondroitin sulfate/dermatan sulfate (DS)/hyaluronic acid (HA), respectively, in B. thetaiotaomicron. The ability of the Bacteroidetes to target highly sulfated host glycans is key to their success in the gut environment but can lead to inflammation in susceptible hosts. Therefore, our continued understanding of the molecular strategies employed by these bacteria to scavenge carbohydrate nutrition is likely to lead to novel ways to alter their metabolism to promote host health. © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected]

Report this publication

Statistics

Seen <100 times