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Hospitalization Increases the Risk of Acute Arthritic Flares in Gout: A Population-based Study over 2 Decades.

Authors
  • Zleik, Nour1, 2
  • Elfishawi, Mohanad M1, 2
  • Kvrgic, Zoran1, 2
  • Michet, Clement J Jr1, 2
  • Crowson, Cynthia S3, 4
  • Matteson, Eric L1, 2
  • Bongartz, Tim1, 2
  • 1 From the Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
  • 2 N. Zleik, MD, Rheumatology Fellow, Division of Rheumatology, Augusta University; M.M. Elfishawi, MD, Internal Medicine Resident, Icahn School of Medicine at Mount Sinai; Z. Kvrgic, CCRP, Study Coordinator, Mayo Clinic; C.J. Michet Jr., MD, Consultant, Mayo Clinic; C.S. Crowson, MS, Associate Professor, Mayo Clinic; E.L. Matteson, MD, MPH, Consultant, Mayo Clinic; T. Bongartz, MD, MS, Vanderbilt University.
  • 3 From the Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA. [email protected]
  • 4 N. Zleik, MD, Rheumatology Fellow, Division of Rheumatology, Augusta University; M.M. Elfishawi, MD, Internal Medicine Resident, Icahn School of Medicine at Mount Sinai; Z. Kvrgic, CCRP, Study Coordinator, Mayo Clinic; C.J. Michet Jr., MD, Consultant, Mayo Clinic; C.S. Crowson, MS, Associate Professor, Mayo Clinic; E.L. Matteson, MD, MPH, Consultant, Mayo Clinic; T. Bongartz, MD, MS, Vanderbilt University. [email protected]
Type
Published Article
Journal
The Journal of rheumatology
Publication Date
Aug 01, 2018
Volume
45
Issue
8
Pages
1188–1191
Identifiers
DOI: 10.3899/jrheum.171320
PMID: 29961683
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To assess in-hospital gout flares in patients with gout. Hospitalizations were evaluated for gout flares in a cohort of Olmsted County, Minnesota, residents with incident gout in 1989-1992 or 2009-2010. There were 429 patients followed up to 5 years. Of these, 169 patients experienced 454 hospitalizations. Hospitalization rates increased without reaching statistical significance from 1989-1992 to 2009-2010 [rate ratio (RR) 1.19, 95% CI 0.98-1.45]. The gout flare rate increased significantly during hospitalization (RR 10.2, 95% CI 6.8-14.5). In-hospital gout flare increased the average hospital stay by 1.8 days (p < 0.001). Hospitalization increased the risk of gout flares 10-fold. In-hospital gout flares were associated with longer hospitalization.

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