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Hormonal steroids indirectly influence insulin binding in rat testis.

Authors
  • Abelé, V
  • Tremblay, R R
Type
Published Article
Journal
Journal of receptor research
Publication Date
Jan 01, 1985
Volume
5
Issue
4
Pages
219–230
Identifiers
PMID: 2997444
Source
Medline
License
Unknown

Abstract

Pituitary LH is a key factor in controlling Leydig cell activity. In order to verify how steroids produced by the male gonads could influence testicular insulin binding, different steroids at varying doses were administered. Testosterone propionate (Tp) as well as estradiol-17 beta (E2-17 beta) and 5 alpha-dihydrotestosterone (DHT) led to a 50% decrease of insulin binding in testis while no effect was noted when HCG was administered concomitantly with DHT. LH receptors were parallely measured: DHT and E2-17 beta significantly depressed testis LH binding. It is concluded that steroids play a role in the regulation of testis membrane insulin receptor via their feedback mechanism on pituitary LH.

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