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Hormonal control of renal phosphoenolpyruvate carboxykinase activity during development of the rat.

Authors
Type
Published Article
Journal
Enzyme
Publication Date
Volume
21
Issue
2
Pages
115–126
Identifiers
PMID: 177277
Source
Medline

Abstract

The effect of injections of hormones in utero on fetal rat kidney and liver extramitochondrial phosphoenolpyruvate carboxykinase activity has been studied. Glucagon and thyroxine induced the liber enzyme but none of the hormones tested affected the renal enzyme. In the postnatal rat, the hepatic phosphoenolpyruvate barboxykinase activity is increased after triamcinolone or thyroxine injection but only triamcinolone injection increases the activity of the kidney enzyme. It is suggested that the rise in renal phosphoenolpyruvate carboxykinase activity at about 10 days of age is due to the increase in blood corticosterone content occurring at the same age.

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