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[Homocysteine and hyperhomocysteinemia].

Authors
  • Laskowska-Klita, T
Type
Published Article
Journal
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Publication Date
Mar 01, 2001
Volume
10
Issue
57
Pages
135–137
Identifiers
PMID: 11398509
Source
Medline
License
Unknown

Abstract

This paper reviews the biochemical and physiological data underlying hyperhomocysteinemia. Elevation of plasma homocysteine arises from disrupted of its metabolism (remethylation to methionine and transsulfuration to cystathionine) and is a function of a complex interaction between multiple genetic and environmental factors. Hyperhomocysteinemia, a conditions that recent epidemiological studies have shown to be associated with an increased risk of vascular diseases, may be a equal importance to hypercholesterolemia, hypertension and smoking in etiology of atherosclerosis. Based on the role of folic acid, vitamin B12 and B6 in homocysteine metabolism supplementation with these vitamins in treatment of hyperhomocysteinemia both in cardiovascular diseases and neural tube defects is reviewed.

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