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Homocysteine and cognitive function in elderly people.

Authors
  • Garcia, Angeles
  • Zanibbi, Katherine
Type
Published Article
Journal
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Publication Date
Oct 12, 2004
Volume
171
Issue
8
Pages
897–904
Identifiers
PMID: 15477631
Source
Medline
License
Unknown

Abstract

Dementia is highly prevalent among elderly people, and projections show that the number of people affected might triple over the next 50 years, mainly because of a large increase in the oldest-old segment of the population. Because of this and the disease's devastating effects, measures for the prevention and early detection of dementia are crucial. Age and years of education are among the most relevant risk factors for dementia, but in recent years the role of homocysteine has also been investigated. Homocysteine is an amino acid produced in the metabolism of methionine, a process dependent on the B vitamins cobalamin, vitamin B6 and folic acid. There is evidence that increased serum homocysteine levels are associated with declining cognitive function and dementia. We review this evidence in addition to the potential mechanisms through which homocysteine acts on the brain to cause cognitive dysfunction, the metabolism of homocysteine and factors associated with alteration of the normal metabolism.

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