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Home Parenteral Nutrition in Patients with Intestinal Failure: Possible Undetected Complications

Authors
  • Santarpia, Lidia
  • Viceconte, Giulio
  • Foggia, Maria
  • Alfonsi, Lucia
  • Tosone, Grazia
  • Camera, Luigi
  • Pagano, Maria Carmen
  • De Simone, Giuseppe
  • Contaldo, Franco
  • Pasanisi, Fabrizio
Publication Date
Mar 09, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Background: Septic pulmonary embolism (SPE) may be a frequently undetected complication of central venous catheter (CVC)-related bloodstream infections (CRBSIs). Materials and Methods: The incidence of SPE was evaluated in a cohort of non-oncological patients on home parenteral nutrition (HPN) who were hospitalized for a CRBSI from January 2013 to December 2017. The main clinical, microbiological, and radiological features and the therapeutic approach were also described. Results: Twenty-three infections over 51,563 days of HPN therapy were observed, corresponding to an infection rate of 0.45/1000. In 10 out of the 23 cases (43.5%), pulmonary lesions compatible with SPE were identified. Conclusion: Our results demonstrated that a CRBSI can produce asymptomatic SPE with lung infiltrates in 43.5% of the cases, suggesting the need to check for secondary lung infections to choose the most appropriate antimicrobial therapy.

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