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[Hobnail variant of papillary thyroid carcinoma].

Authors
  • Da Cruz, Vanessa1
  • Lopez, Jonathan2
  • Lifante, Jean Christophe3
  • Decaussin-Petrucci, Myriam4
  • 1 Service d'anatomie et cytologie pathologiques, CHU de Lyon-Sud, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France. Electronic address: [email protected] , (France)
  • 2 Laboratoire de biochimie et biologie moléculaire, CHU de Lyon-Sud, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France. , (France)
  • 3 Service de chirurgie digestive et endocrinienne, CHU de Lyon-Sud, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France. , (France)
  • 4 Service d'anatomie et cytologie pathologiques, CHU de Lyon-Sud, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France; Inserm1052 CNRS5286, Cancer Research Center of Lyon, Lyon 1 University, Lyon, France. , (France)
Type
Published Article
Journal
Annales de Pathologie
Publisher
Elsevier
Publication Date
Apr 01, 2021
Volume
41
Issue
2
Pages
201–206
Identifiers
DOI: 10.1016/j.annpat.2020.10.004
PMID: 33272718
Source
Medline
Keywords
Language
French
License
Unknown

Abstract

We report the case of a hobnail variant of papillary thyroid carcinoma revealed by a cervical mass in a 67 years-old patient. This new entity in the 2017 WHO classification is rare. Histopathological diagnosis is based on four main criteria, present in≥30% of tumor cells: a discohesive tumor, micropapillary structures and loss of cell polarity and hobnail cells. This tumor expresses markers of thyroid differentiation. The most widely described molecular alteration is BRAF V600E mutation associated with other alterations, especially p53 mutations. This reflects the agressivness of this variant. It is important to recognize the hobnail variant of papillary thyroid carcinoma and to specify it in the pathological report because of its more pejorative prognosis, with local invasion, lymph node and distant metastasis, and deacreased survival. No specific management is recommended, but a close follow up seems necessary. Copyright © 2020 Elsevier Masson SAS. All rights reserved.

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