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HLA-G expression during hookworm infection in pregnant women.

Authors
  • Avokpaho, Euripide1
  • d'Almeida, Tania C1
  • Sadissou, Ibrahim2
  • Tokplonou, Léonidas3
  • Adamou, Rafiou3
  • Sonon, Paulin2
  • Milet, Jacqueline1
  • Cottrell, Gilles1
  • Mondière, Amandine1
  • Massougbodji, Achille4
  • Moutairou, Kabirou4
  • Donadi, Eduardo A5
  • Teixeira Mendes Junior, Celso6
  • Favier, Benoit7
  • Carosella, Edgardo7
  • Moreau, Philippe7
  • Rouas-Freiss, Nathalie7
  • Garcia, André1
  • Courtin, David8
  • 1 MERIT, Institut de Recherche pour le Développement (IRD), Université Sorbonne Paris Cité, Université Paris Descartes, France. , (France)
  • 2 MERIT, Institut de Recherche pour le Développement (IRD), Université Sorbonne Paris Cité, Université Paris Descartes, France; Université d'Abomey-Calavi, Cotonou, Benin; Division of Clinical Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. , (Benin)
  • 3 MERIT, Institut de Recherche pour le Développement (IRD), Université Sorbonne Paris Cité, Université Paris Descartes, France; Université d'Abomey-Calavi, Cotonou, Benin. , (Benin)
  • 4 Université d'Abomey-Calavi, Cotonou, Benin. , (Benin)
  • 5 Division of Clinical Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. , (Brazil)
  • 6 Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Brazil. , (Brazil)
  • 7 CEA, Institut des Maladies Emergentes et des Thérapies Innovantes (IMETI), Service de Recherche en Hémato-Immunologie (SRHI), Hôpital Saint-Louis, IUH, Paris, France; Université Paris Diderot, Sorbonne Paris Cite, IUH, Hôpital Saint-Louis, UMRE5, IUH, Paris, France. , (France)
  • 8 MERIT, Institut de Recherche pour le Développement (IRD), Université Sorbonne Paris Cité, Université Paris Descartes, France. Electronic address: [email protected] , (France)
Type
Published Article
Journal
Acta tropica
Publication Date
Aug 01, 2019
Volume
196
Pages
52–59
Identifiers
DOI: 10.1016/j.actatropica.2019.04.026
PMID: 31078470
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

HLA-G plays a key role on immune tolerance. Pathogens can induce soluble HLA-G (sHLA-G) production to down-regulate the host immune response, creating a tolerogenic environment favorable for their dissemination. To our knowledge, no study has yet been conducted to assess the relationship between sHLA-G and geohelminth infections. The study was conducted in Allada, Southeastern Benin, from 2011-2014. The study population encompassed 400 pregnant women, included before the end of the 28th week of gestation and followed-up until delivery. At two antenatal care visits and at delivery, stool and blood samples were collected. Helminths were diagnosed by means of the Kato-Katz concentration technique. We used quantile regression to analyze the association between helminth infections and sHLA-G levels during pregnancy. sHLA-G levels gradually increased during pregnancy and reached maximal levels at delivery. Prevalence of helminth infections was low, with a majority of hookworm infections. We found significantly more hookworm-infected women above the 80th quantile (Q80) of the distribution of the mean sHLA-G level (p < 0.03, multivariate quantile regression). Considering only women above the Q80 percentile, the mean sHLA-G level was significantly higher in hookworm-infected compared to uninfected women (p = 0.04). High levels of sHLA-G were associated with hookworm infection in pregnant women. This result is consistent with the potential involvement of sHLA-G in immune tolerance induced by helminths during pregnancy. Copyright © 2019 Elsevier B.V. All rights reserved.

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