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HLA, Gm, and Km polymorphisms and immunity to infectious diseases in South Amerinds.

Authors
  • Black, F L
  • Schiffman, G
  • Pandey, J P
Type
Published Article
Journal
Experimental and clinical immunogenetics
Publication Date
Jan 01, 1995
Volume
12
Issue
3
Pages
206–216
Identifiers
PMID: 8534507
Source
Medline
License
Unknown

Abstract

Isolated South Amerinds, a population at very high risk from infectious disease, mount good immune responses to pneumococcal polysaccharides, viral antigens and other immunogens. No unusual immunoglobulin allotype or HLA antigen, which might explain the high risk from infectious disease, was found among them. Responses are examined in relation to the immunogenetic markers that are most prevalent. Amerinds with Gm 1,2,17,21 responded less well than persons without this haplotype to 10 of 12 pneumococcal polysaccharides, and those who were homozygous at the HLA class I loci responded less well to viral antigens. However, these differences are not strong and there are few such findings relative to the number of possibilities examined. The most distinctive immunogenetic characteristic of these populations is their low level of polymorphism at all tested loci. Their susceptibility to infectious agents can be attributed to this genetic uniformity and a consequent ability of pathogens to adapt to the population.

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