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HLA-G and immune evasion in cancer cells.

Authors
  • Sheu, Jim
  • Shih, Ie-Ming
Type
Published Article
Journal
Journal of the Formosan Medical Association = Taiwan yi zhi
Publication Date
Apr 01, 2010
Volume
109
Issue
4
Pages
248–257
Identifiers
DOI: 10.1016/S0929-6646(10)60050-2
PMID: 20434034
Source
Medline
License
Unknown

Abstract

Acquisition of novel gene products or new antigens in cancer cells elicits a host immune response that results in selection pressure for tumor clones to evade immunosurveillance. Similar to maternal-fetal tolerance and allotransplantation acceptance, upregulation of HLA-G expression has been found as one of the mechanisms that are programmed in cancer cells. HLA-G expression is frequently detected in a wide variety of human cancers and its protein levels negatively correlate with poor clinical outcome. The immune inhibitory effect can be achieved by binding of HLA-G molecules to the immunoglobulin-like inhibitory receptors that are expressed on the immunocompetent cells at all stages of the immune response. This review summarizes recent studies of HLA-G expression in human cancer, with a special focus on the molecular mechanisms that underlie how HLA-G molecules facilitate tumor cell evasion of the host immune response, and presents new directions for developing HLA-G-based diagnosis/therapeutics.

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