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HLA DR antigens in rheumatoid arthritis.

Authors
Type
Published Article
Journal
Scandinavian journal of rheumatology
Publication Date
Volume
12
Issue
3
Pages
241–245
Identifiers
PMID: 6604939
Source
Medline
License
Unknown

Abstract

The prevalence and possible prognostic significance of HLA-DR antigens have been studied in 129 patients with seropositive (RF-positive) classical rheumatoid arthritis (RA). HLA-DR4 was increased in RA, whilst HLA-DR2 was decreased, though it was not associated with either low titres of RF or with good prognosis. HLA-DR3-positive patients had the highest prevalence of antibodies to nuclear antigens, and the antigen correlated negatively to the presence of subcutaneous nodules, bony erosions and familial RA. RA patients possessing DR3 thus had some of the characteristics of SLE. HLA-DR5 was not present in male RA patients. An absence of familial RA was observed among DRw8-positive patients.

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