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HLA-DQ genotyping combined with serological markers for the diagnosis of celiac disease: is intestinal biopsy still mandatory?

Authors
  • Clouzeau-Girard, Haude
  • Rebouissoux, Laurent
  • Taupin, Jean-Luc
  • Le Bail, Brigitte
  • Kalach, Nicolas
  • Michaud, Laurent
  • Dabadie, Alain
  • Olives, Jean-Pierre
  • Blanco, Patrick
  • Morali, Alain
  • Moreau, Jean-François
  • Lamireau, Thierry
Type
Published Article
Journal
Journal of Pediatric Gastroenterology and Nutrition
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jun 01, 2011
Volume
52
Issue
6
Pages
729–733
Identifiers
DOI: 10.1097/MPG.0b013e31820a724d
PMID: 21593645
Source
Medline
License
Unknown

Abstract

The association of positive HLA-DQ2/DQ8 and serologic testing has a high predictive value for CD. We suggest that symptomatic children with high titers of immunoglobulin (Ig)A tTG could be diagnosed as patients with CD without performing jejunal biopsy. In other children, HLA-DQ2/DQ8 could be useful to exclude the diagnosis of CD if negative. In cases of low IgA tTG titers or in patients with IgA deficiency, intestinal biopsy remains mandatory.

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