HLA Class II-specific antibodies can react with T cells in flow cytometry crossmatch: a case report.
- Published Article
- Publication Date
Dec 01, 2007
HLA Class I-specific antibodies are usually detected using a flow cytometry HLA crossmatch using T cells. A positive case is shown as a single, right-shifted peak on the anti-IgG FITC histogram of T cells. We report a case showing 2 peaks occurring concurrently, both positive and negative. The positive peak resulted from the binding of HLA Class II-specific antibodies to donor-activated T cells expressing the HLA-DR antigens. This case suggested donor-specific HLA Class II-specific antibodies can bind to some T cells as well as to whole B cells.
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This record was last updated on 07/03/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/18089415