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HLA class I and II typing of the patients with Behçet's disease in Saudi Arabia.

Authors
  • Yabuki, K
  • Ohno, S
  • Mizuki, N
  • Ando, H
  • Tabbara, K F
  • Goto, K
  • Nomura, E
  • Nakamura, S
  • Ito, N
  • Ota, M
  • Katsuyama, Y
  • Inoko, H
Type
Published Article
Journal
Tissue antigens
Publication Date
Sep 01, 1999
Volume
54
Issue
3
Pages
273–277
Identifiers
PMID: 10519364
Source
Medline
License
Unknown

Abstract

Thirteen Saudi Arabian patients with Behçet's disease (BD) were typed for HLA-A and -B alleles by the conventional serologic typing and for HLA-DRB1, -DQB1 and -DPB1 alleles by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. As a result, the phenotype frequency of the B51 antigen was significantly increased in the patient group as compared to the ethnically matched control group (76.9% in patients vs. 22.20% in controls), but no significant difference was observed in HLA-A, -DRB1, -DQB1 or -DPB1 alleles between the patients and controls, as previously observed in Japanese BD. Further, by HLA-B51 allelic genotyping performed by the polymerase chain reaction-sequence specific primers (PCR-SSP) method, all of the B51-positive patients and controls were found to carry one particular allele, B*5101, except one patient with B*5108.

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