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HLA-A2 and type 2 (insulin independent) diabetes mellitus in Pima Indians: an association of allele frequency with age.

Authors
  • Williams, R C
  • Knowler, W C
  • Butler, W J
  • Pettitt, D J
  • Lisse, J R
  • Bennett, P H
  • Mann, D L
  • Johnson, A H
  • Terasaki, P I
Type
Published Article
Journal
Diabetologia
Publication Date
Nov 01, 1981
Volume
21
Issue
5
Pages
460–463
Identifiers
PMID: 7297796
Source
Medline
License
Unknown

Abstract

In Pima Indians with Type 2 (insulin independent) diabetes mellitus, HLA-A2 allele frequencies were inversely associated with age, (0.72, 0.59, and 0.52 in those less than 35, 35 to 54, and 55 years old and over, respectively). This suggests that there may be a gene closely linked with the HLA-A locus which plays a role in the expression of diabetes in the Pimas by contributing to an earlier age of onset. HLA-A2 was found in 65% non-diabetic and 81% of 191 diabetic subjects (relative risk = 2.2).

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