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HLA A2 allele is associated with age at onset of Alzheimer's disease.

Authors
  • Ballerini, C
  • Nacmias, B
  • Rombolà, G
  • Marcon, G
  • Massacesi, L
  • Sorbi, S
Type
Published Article
Journal
Annals of neurology
Publication Date
Mar 01, 1999
Volume
45
Issue
3
Pages
397–400
Identifiers
PMID: 10072057
Source
Medline
License
Unknown

Abstract

The prevalence of the HLA A2 allele was investigated in a group of Italian patients with sporadic and early-onset familial Alzheimer's disease (AD and FAD) to analyze the potential association of this allele with early age of onset of the disease. The possible interaction between the HLA A2 allele and apolipoprotein E epsilon4 allele was analyzed. Our data suggest that A2 and epsilon4 alleles may have additive effects on AD onset, and that A2 may play an important role in determining or contributing to a very early age at onset. These findings further support the hypothesis of the involvement of an immune/inflammatory mechanism in the pathogenesis of AD.

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