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HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective.

Authors
  • Kløverpris, Henrik N
  • Stryhn, Anette
  • Harndahl, Mikkel
  • Carlson, Jonathan M
  • Leslie, Alasdair J
  • Chen, Fabian
  • Riddell, Lynn
  • Mulenga, Joseph
  • Walker, Bruce D
  • Ndung'u, Thumbi
  • Buus, Søren
  • Goulder, Philip
Type
Published Article
Journal
AIDS
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jul 17, 2013
Volume
27
Issue
11
Pages
1717–1723
Identifiers
DOI: 10.1097/QAD.0b013e32836146cd
PMID: 23525031
Source
Medline
License
Unknown

Abstract

This study is consistent with previous data showing that HLA-A-restricted Gag-specific responses can impose selection pressure on HIV. In the case of HLA-A*68:02 the Gag response is subdominant, and apparently has little impact in natural infection. However, these data suggest the potential for high frequency vaccine-induced Gag responses restricted by this allele to have significant antiviral efficacy in vaccine recipients.

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