Affordable Access

deepdyve-link
Publisher Website

HIV-1 p6 — a structured to flexible multifunctional membrane-interacting protein

Authors
  • Solbak, Sara Marie Øie
  • Reksten, Tove Ragna
  • Hahn, Friedrich
  • Wray, Victor
  • Henklein, Petra
  • Henklein, Peter
  • Halskau, Øyvind
  • Schubert, Ulrich
  • Fossen, Torgils
Type
Published Article
Journal
Biochimica et Biophysica Acta (BBA) - Biomembranes
Publisher
Elsevier
Publication Date
Jan 01, 2012
Accepted Date
Nov 06, 2012
Volume
1828
Issue
2
Pages
816–823
Identifiers
DOI: 10.1016/j.bbamem.2012.11.010
Source
Elsevier
Keywords
License
Unknown

Abstract

Highlights► HIV-1 p6 exhibits N- and C-terminal helical domains in micelle solution at pH 7. ► p6 interacts with a cytoplasmic model membrane through N- and C-terminal regions. ► Phosphorylation of Ser-40 does not alter the secondary structure of the protein. ► Phosphorylation of Ser-40 amplifies the interaction of p6 with membranes. ► Effects of p6 S40F mutation indicate p6 modulates membrane interactions of HIV Gag.

Report this publication

Statistics

Seen <100 times