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HIV vaccine design: insights from live attenuated SIV vaccines

Authors
  • Koff, Wayne C1
  • Johnson, Philip R2
  • Watkins, David I3
  • Burton, Dennis R4
  • Lifson, Jeffrey D5
  • Hasenkrug, Kim J6
  • McDermott, Adrian B1
  • Schultz, Alan1
  • Zamb, Timothy J1
  • Boyle, Rosanne1
  • Desrosiers, Ronald C7
  • 1 International AIDS Vaccine Initiative, New York, New York, 10038, USA , New York (United States)
  • 2 The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104-4318, USA , Philadelphia (United States)
  • 3 University of Wisconsin, Madison, Wisconsin, 53706-1532, USA , Madison (United States)
  • 4 Scripps Research Institute, La Jolla, California, 92037, USA , La Jolla (United States)
  • 5 Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, Science Applications International Corporation Frederick, National Cancer Institute-Frederick, Frederick, Maryland, 21702, USA , Frederick (United States)
  • 6 Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, 59840, USA , Hamilton (United States)
  • 7 Harvard Medical School New England Regional Primate Research Center, Southborough, Massachusetts, 01772, USA , Southborough (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Dec 15, 2005
Volume
7
Issue
1
Pages
19–23
Identifiers
DOI: 10.1038/ni1296
Source
Springer Nature
License
Yellow

Abstract

The International AIDS Vaccine Initiative has established a consortium to elucidate mechanisms of protection conferred by live attenuated simian immunodeficiency virus vaccines in monkeys. Here, the strategies defining key components of the protective immune response elicited by these vaccines are discussed.

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