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HIV Prevention Efforts and Incidence of HIV in Uganda.

Authors
  • Grabowski, M Kate1
  • Serwadda, David M1
  • Gray, Ronald H1
  • Nakigozi, Gertrude1
  • Kigozi, Godfrey1
  • Kagaayi, Joseph1
  • Ssekubugu, Robert1
  • Nalugoda, Fred1
  • Lessler, Justin1
  • Lutalo, Thomas1
  • Galiwango, Ronald M1
  • Makumbi, Fred1
  • Kong, Xiangrong1
  • Kabatesi, Donna1
  • Alamo, Stella T1
  • Wiersma, Steven1
  • Sewankambo, Nelson K1
  • Tobian, Aaron A R1
  • Laeyendecker, Oliver1
  • Quinn, Thomas C1
  • And 3 more
  • 1 From the Department of Pathology (M.K.G., A.A.R.T.) and the Division of Infectious Diseases, Department of Medicine (O.L., T.C.Q., S.J.R., L.W.C.), Johns Hopkins School of Medicine, and the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health (M.K.G., R.H.G., J.L., X.K., A.A.R.T., O.L., T.C.Q., S.J.R., M.J.W., L.W.C.), Baltimore, and the Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda (O.L., T.C.Q., S.J.R.) - all in Maryland; and Rakai Health Sciences Program, Entebbe (M.K.G., D.M.S., R.H.G., G.N., G.K., J.K., R.S., F.N., T.L., R.M.G., F.M., N.K.S., A.A.R.T., S.J.R., M.J.W., L.W.C.), and Centers for Disease Control and Prevention (D.K., S.T.A., S.W.), Makerere University School of Public Health (D.M.S., F.M.), and Makerere University School of Medicine (N.K.S.), Kampala - all in Uganda. , (Uganda)
Type
Published Article
Journal
New England Journal of Medicine
Publisher
New England Journal of Medicine
Publication Date
Nov 30, 2017
Volume
377
Issue
22
Pages
2154–2166
Identifiers
DOI: 10.1056/NEJMoa1702150
PMID: 29171817
Source
Medline
License
Unknown

Abstract

In this longitudinal study, the incidence of HIV infection declined significantly with the scale-up of a combination strategy for HIV prevention, which provides empirical evidence that interventions for HIV prevention can have a population-level effect. However, additional efforts are needed to overcome disparities according to sex and to achieve greater reductions in the incidence of HIV infection. (Funded by the National Institute of Allergy and Infectious Diseases and others.).

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