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HIV and Ischemic Heart Disease.

Authors
  • Vachiat, Ahmed1
  • McCutcheon, Keir1
  • Tsabedze, Nqoba1
  • Zachariah, Don1
  • Manga, Pravin2
  • 1 Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa. , (South Africa)
  • 2 Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa. Electronic address: [email protected] , (South Africa)
Type
Published Article
Journal
Journal of the American College of Cardiology
Publication Date
Jan 03, 2017
Volume
69
Issue
1
Pages
73–82
Identifiers
DOI: 10.1016/j.jacc.2016.09.979
PMID: 28057253
Source
Medline
Keywords
License
Unknown

Abstract

The association of coronary heart disease (CHD) and human immunodeficiency virus (HIV) infection has been well recognized for many years. The etiology of the increased prevalence of CHD in HIV-infected populations is the result of complex interactions among the viral infection, host factors, traditional risk factors, and therapies for HIV. As the HIV population is living longer, largely attributable to combination antiretroviral therapy, there is concern about the effect of the rising prevalence of CHD on morbidity and mortality, as well its effect on health systems around the world. This review will highlight the epidemiological evidence linking HIV infection and CHD. It will also focus on our current understanding of the pathogenesis and factors associated with HIV infection and CHD. In addition, the review will highlight modes of presentation and management strategies for mitigating risk and treatment of HIV-positive patients presenting with CHD.

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