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HIV-1 transcription: activation mediated by acetylation of Tat.

Authors
  • Nakatani, Yoshihiro
Type
Published Article
Journal
Structure
Publisher
Elsevier BV
Publication Date
Apr 01, 2002
Volume
10
Issue
4
Pages
443–444
Identifiers
PMID: 11937047
Source
Medline
License
Unknown

Abstract

Acetylation of HIV-1 Tat stimulates transcriptional elongation by dissociating Tat from TAR, a transactivation response RNA element in nascent HIV-1 transcripts. In the March issue of Molecular Cell, Mujtaba et al. show that the bromodomain of PCAF acetylase specifically binds to acetylated Tat and leads to dissociation of Tat from TAR.

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