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HIV-1 Nef drives macrophages into hiding.

Authors
  • Morley, Sharon Celeste1
  • 1 WASHINGTON UNIVERSITY SCHOOL OF MEDICINE.
Type
Published Article
Journal
Blood
Publisher
American Society of Hematology
Publication Date
Mar 05, 2015
Volume
125
Issue
10
Pages
1512–1513
Identifiers
DOI: 10.1182/blood-2015-01-618983
PMID: 25745180
Source
Medline
License
Unknown

Abstract

In this issue of Blood, Vérollet et al show that expression of the HIV-1–derived protein Nef alters the migratory mode adopted by macrophages, enhancing macrophage tissue infiltration and explaining the observed accumulation of tissue-resident macrophages in some HIV-infected patients.

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