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HIV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth hormone.

Authors
  • Mellado, M
  • Llorente, M
  • Rodríguez-Frade, J M
  • Lucas, P
  • Martínez, C
  • del Real, G
Type
Published Article
Journal
Vaccine
Publisher
Elsevier
Publication Date
Jul 01, 1998
Volume
16
Issue
11-12
Pages
1111–1115
Identifiers
PMID: 9682366
Source
Medline
License
Unknown

Abstract

Immunization of mice with HIV-1-gp120 results in predominant activation of the Th2 lymphocyte subset, leading to enhanced IL-4 production. Administration of human growth hormone at the time of gp120 immunization provokes a change in the cytokine production pattern, with lower IL-4 and higher gamma-IFN and IL-2 synthesis levels, indicating a preferential switch in stimulation from Th2 to Th1 cells. A growth hormone would thus be of great use for pharmacological intervention in those cases in which an infectious microorganism evades immune defenses by provoking a Th2 response. In addition, the ability of growth hormone to induce a Th1-type response upon vaccination with an HIV-antigen should be examined in the development of new therapeutic strategies or in the design of novel vaccines against HIV infection.

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