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A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid.

Authors
  • Forbes, S
  • Godsland, I F
  • Taylor-Robinson, S D
  • Bell, J D
  • Thomas, E L
  • Patel, N
  • Hamilton, G
  • Parker, K H
  • Marshall, I
  • Gray, C D
  • Bedford, D
  • Caslake, M
  • Walker, B R
  • Johnston, D G
Type
Published Article
Journal
Diabetologia
Publisher
Springer-Verlag
Publication Date
Sep 01, 2013
Volume
56
Issue
9
Pages
2021–2033
Identifiers
DOI: 10.1007/s00125-013-2956-3
PMID: 23760677
Source
Medline
License
Unknown

Abstract

pGDM is associated with increased IHCL independently of adiposity. The increased liver fat contributes to the phenotype, but pGDM status is independently associated with diminished insulin secretion and (shown for the first time) augmented VLDL metabolism. IHCL with pGDM may compound a dysmetabolic phenotype.

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