The first epidemic of dengue reported in the Americas occurred in the eighteenth century in Philadelphia, North of the United States of America and was first described in 1780 by Benjamin Rush; curiously in a cold climate zone. Since that outbreak, dengue has affected most of the countries in the region, but the most significant number of cases is concentrated in Latin America and the Caribbean. Dengue can be caused by any of the four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) and is transmitted by the mosquitoes Aedes aegypti and Aedes albopictus; mainly urban vectors with high adaptability and resistance to insecticides. These mosquitoes circulate primarily in countries of Latin America and the Caribbean, Southeast Asia and in the Western Pacific islands. Although dengue is considered a tropical infectious disease, autochthonous cases have been reported in the south of the United States and some countries in Europe such as Italy, France, Greece, and Spain.