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Histone crotonylation-centric gene regulation

Authors
  • Li, Kun1
  • Wang, Ziqiang1, 2
  • 1 The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China , Jinan (China)
  • 2 Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250062, China , Jinan (China)
Type
Published Article
Journal
Epigenetics & Chromatin
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 06, 2021
Volume
14
Issue
1
Identifiers
DOI: 10.1186/s13072-021-00385-9
Source
Springer Nature
Keywords
License
Green

Abstract

Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histone crotonylation at DNA regulatory elements plays an important role in the activation of gene transcription. However, among others, we have shown that elevated cellular crotonylation levels result in the inhibition of endocytosis-related gene expression and pro-growth gene expression, implicating the complexity of histone crotonylation in gene regulation. Therefore, it is important to understand how histone crotonylation is regulated and how it, in turn, regulates the expression of its target genes. In this review, we summarize the regulatory factors that control histone crotonylation and discuss the role of different histone crotonylation sites in regulating gene expression, while providing novel insights into the central role of histone crotonylation in gene regulation.

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