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The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer.

Authors
  • Chen, Zhiwei
  • Ye, Xiangyun
  • Tang, Naiwang
  • Shen, Shengping
  • Li, Ziming
  • Niu, Xiaomin
  • Lu, Shun
  • Xu, Ling
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jul 01, 2014
Volume
171
Issue
13
Pages
3196–3211
Identifiers
DOI: 10.1111/bph.12661
PMID: 24571482
Source
Medline
Keywords
License
Unknown

Abstract

hMOF was overexpressed in human NSCLC and was a predictor of poor survival. hMOF-mediated Nrf2 acetylation and nuclear retention are essential for anti-oxidative and anti-drug responses. hMOF may provide a therapeutic target for the treatment of NSCLC.

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