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Histometric study of socket healing after tooth extraction in rats treated with diclofenac.

Authors
Type
Published Article
Journal
Brazilian Dental Journal
0103-6440
Publisher
SciELO
Publication Date
Volume
13
Issue
2
Pages
92–96
Identifiers
PMID: 12238809
Source
Medline

Abstract

The purpose of the present study was to investigate if diclofenac administration interferes with the time course of alveolar wound healing in rats. Forty-two Wistar rats were used, 21 rats received 10 mg/kg/day of diclofenac one day before and 4 days after extraction of the right maxillary incisors and 21 rats received saline. The animals were sacrificed 7, 14 and 21 days after tooth extraction. Progressive new bone formation and a decrease in the volume fraction of blood clot and connective tissue from 1 to 3 weeks after tooth extraction was quantified using the histometric point-counting method. Diclofenac treatment caused a significant delay in new bone formation in association with an impairment of blood clot remission/organization.

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