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Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Authors
  • Dolby, Heather W1
  • Potey, Philippe1
  • Wilder-Smith, Annika B1
  • Clohisey, Sara2
  • Millar, Jonathan E2
  • Baillie, J Kenneth2
  • Dorward, David A1
  • Lucas, Christopher D1
  • Russell, Clark D1, 2
  • 1 University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, United Kingdom , (United Kingdom)
  • 2 Roslin Institute, Division of Genetics and Genomics, University of Edinburgh, United Kingdom , (United Kingdom)
Type
Published Article
Journal
Open Forum Infectious Diseases
Publisher
Oxford University Press
Publication Date
Dec 28, 2020
Volume
8
Issue
2
Identifiers
DOI: 10.1093/ofid/ofaa640
PMID: 33553478
PMCID: PMC7798721
Source
PubMed Central
Keywords
Disciplines
  • AcademicSubjects/MED00290
License
Unknown

Abstract

Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

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