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Histological effects of pharmacologically active human bile acid nano/micro-particles in Type-1 diabetes.

Authors
  • Mathavan, Sangeetha1
  • Ionescu, Corina M2
  • Kovacevic, Bozica1
  • Mikov, Momir3
  • Golocorbin-Kon, Svetlana4
  • Mooranian, Armin1
  • Dass, Crispin R5
  • Al-Salami, Hani1
  • 1 Biotechnology & Drug Development Research Laboratory, School of Pharmacy & Biomedical Science, Curtin Health Innovation Research Institute, Curtin University, Perth WA, Australia. , (Australia)
  • 2 Molecular Biology & Biotechnology Department, Babes-Bolyai University, Cluj-Napoca, Romania. , (Oman)
  • 3 Department of Pharmacology, Toxicology & Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia. , (Serbia)
  • 4 Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia. , (Serbia)
  • 5 School of Pharmacy & Biomedical Science, Curtin University, Perth WA, Australia. , (Australia)
Type
Published Article
Journal
Therapeutic Delivery
Publisher
"Future Science, LTD"
Publication Date
Mar 01, 2020
Volume
11
Issue
3
Pages
157–171
Identifiers
DOI: 10.4155/tde-2019-0079
PMID: 32046598
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Aim: Gliclazide (G) is a drug prescribed for Type 2 diabetics, although recent studies suggest it has desirable effects in both types of diabetes, Type 1 diabetes and Type 2 diabetes. G has an inconsistent absorption due to poor formulation and bile acids (BAs) have shown significant promise in drug formulation optimization. Hence, the study aimed to examine G effects on histopathological, anti-inflammatory and antidiabetic effects when encapsulated with BAs. Materials & methods: Rats were randomized into eight groups, of which seven were made Type 1 diabetes and treated with various BA-based treatments. Tissue histopathology, inflammation and the bile acid profile were analyzed. Results & conclusion: G capsules showed no histological but the most anti-inflammatory effects, which suggest significant beneficial effects in diabetes treatment.

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