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Histamine and Tissue Fibrinolytic Activity in Duodenal Ulcer Disease

Authors
  • Ben-Hamida, Abduljalil
  • Adekunie, Adedoyin
  • Wing, Adesanya
  • Man, Kee
  • Spencer, John
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Jan 01, 1998
Volume
43
Issue
1
Pages
126–132
Identifiers
DOI: 10.1023/A:1018888423882
Source
Springer Nature
Keywords
License
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Abstract

Patients with duodenal ulcer have lowergastroduodenal mucosal histamine and a reduced tissuefibrinolysis at the ulcer edge. In the duodenal mucosafibrinolysis is regulated by the tissue-type andurokinase-type plasminogen activators; and inhibitors type 1and type 2. Trends across ordered groups leading frommucosa of nonulcer control subjects,“normal” mucosa of ulcer patients, to ulceredge were found in tissue-type plasminogen activatorconcentration, histamine concentration, and histaminemethyltransferase activity. Concentrations oftissue-type activator, inhibitor type 1, and histaminewere significantly lower at ulcer edge than at normal. An inversecorrelation was found between histaminemethyltransferase and plasminogen activator activities,methyltransferase and tissue-type activator, andmethyltransferase and histamine. These results support thehypothesis that in active ulceration, reduction intissue fibrinolytic activity is closely associated withenhanced release and metabolism of histamine.

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