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Histamine modulation of acute nociception involves regulation of Nav 1.8 in primary afferent neurons in mice.

Authors
  • Yu, Jie
  • Fang, Qi
  • Lou, Guo-Dong
  • Shou, Wen-Ting
  • Yue, Jia-Xing
  • Tang, Ying-Ying
  • Hou, Wei-Wei
  • Xu, Tian-Le
  • Ohtsu, Hiroshi
  • Zhang, Shi-Hong
  • Chen, Zhong
Type
Published Article
Journal
CNS Neuroscience & Therapeutics
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 01, 2013
Volume
19
Issue
9
Pages
649–658
Identifiers
DOI: 10.1111/cns.12134
PMID: 23773488
Source
Medline
Keywords
License
Unknown

Abstract

Our results indicate that histamine participates in acute pain modulation in a dose-related manner. The regulation of Nav 1.8 expression and the excitability of nociceptive primary afferent neurons may be involved in the underlying mechanisms.

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