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Hirschsprung's disease and medullary thyroid carcinoma: 15-year experience with molecular genetic screening of the RET proto-oncogene.

Authors
  • Vaclavikova, Eliska
  • Kavalcova, Lucie
  • Skaba, Richard
  • Dvorakova, Sarka
  • Macokova, Pavla
  • Rouskova, Blanka
  • Bendlova, Bela
Type
Published Article
Journal
Pediatric Surgery International
Publisher
Springer-Verlag
Publication Date
Feb 01, 2012
Volume
28
Issue
2
Pages
123–128
Identifiers
DOI: 10.1007/s00383-011-2993-2
PMID: 21986619
Source
Medline
License
Unknown

Abstract

Results show the benefit of systematic RET mutation screening in HD patients in order to identify the risk of MTC in the preclinical stage of the disease. All patients should be tested for RET mutations at least in exon 10, and now additionally in exon 11 and 13, as well.

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