Affordable Access

deepdyve-link
Publisher Website

Hippocampal-striatal functional connectivity supports processing of temporal expectations from associative memory.

Authors
  • van de Ven, Vincent1
  • Lee, Chanju1
  • Lifanov, Julia2
  • Kochs, Sarah1
  • Jansma, Henk1
  • De Weerd, Peter1
  • 1 Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands. , (Netherlands)
  • 2 University of Birmingham, Birmingham, UK.
Type
Published Article
Journal
Hippocampus
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 01, 2020
Volume
30
Issue
9
Pages
926–937
Identifiers
DOI: 10.1002/hipo.23205
PMID: 32275344
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The hippocampus and dorsal striatum are both associated with temporal processing, but they are thought to play distinct roles. The hippocampus has been reported to contribute to storing temporal structure of events in memory, whereas the striatum contributes to temporal motor preparation and reward anticipation. Here, we asked whether the striatum cooperates with the hippocampus in processing the temporal context of memorized visual associations. In our task, participants were trained to implicitly form temporal expectations for one of two possible time intervals associated to specific cue-target associations, and subsequently were scanned using ultra-high-field 7T functional magnetic resonance imaging. During scanning, learned temporal expectations could be violated when the pairs were presented at either the associated or not-associated time intervals. When temporal expectations were met during testing trials, activity in left and right hippocampal subfields and right putamen decreased, compared to when temporal expectations were not met. Further, psycho-physiological interactions showed that functional connectivity between left hippocampal subfields and caudate decreased when temporal expectations were not met. Our results indicate that the hippocampus and striatum cooperate to process implicit temporal expectation from mnemonic associations. Our findings provide further support for a hippocampal-striatal network in temporal associative processing. © 2020 The Authors. Hippocampus published by Wiley Periodicals, Inc.

Report this publication

Statistics

Seen <100 times