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Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia.

  • McKeever, Anna
  • Paris, Alvar F
  • Cullen, James
  • Hayes, Lawrence
  • Ritchie, Craig W
  • Ritchie, Karen
  • Waldman, Adam D
  • Wells, Katie
  • Busza, Albert
  • Carriere, Isabelle
  • O'Brien, John
  • Su, Li
Publication Date
Jan 01, 2020
Apollo - University of Cambridge Repository
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ABSTRACT BACKGROUND: Alzheimer’s Disease (AD) begins decades before the onset of dementia. There is a need to investigate biomarkers of early AD for use in clinical trials and to facilitate early intervention. OBJECTIVE: We aimed to determine whether changes in hippocampal subfield volumes in healthy middle-aged adults were associated with risk of future dementia. METHODS: We included 150 participants from the PREVENT-Dementia cohort, which recruited subjects aged 40-59 with or without a family history of dementia (FHD; included here were 81 with FHD and 69 without). Hippocampal subfield volumes were segmented from high resolution T2-weighted 3T MRI images taken at baseline and 2-year follow-up. RESULTS: FHD and greater 20 year-risk of dementia due to cardiovascular risk factors were both associated with lower CA1 volume. FHD was also associated with a relative increase in combined CA3, CA4 and dentate gyrus volume between baseline and follow-up. CONCLUSION: CA1 atrophy may commence as early as middle-age in those with a high risk of future dementia, while increases in CA3, CA4 and dentate gyrus volume may be a response to early AD in the form of inflammation or neurogenesis.

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