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The high-risk HPV infection and urinary system tumor

Authors
  • Yang, Wenyan
Type
Published Article
Journal
Infection International
Publisher
De Gruyter Open
Publication Date
Apr 10, 2018
Volume
6
Issue
4
Pages
108–111
Identifiers
DOI: 10.2478/ii-2018-0004
Source
De Gruyter
Keywords
License
Yellow

Abstract

HPV is classified into high-risk and low-risk types depending on its probability of leading to tumorigenesis. Many studies have shown that HPV infection, especially the infection caused by the high-risk type, is always related to prostate cancer, bladder cancer, penile cancer, testicular cancer, and other urinary system tumors. However, previous studies differed in sexual openness and racial genetic susceptibility of the study object, sample size, and experimental methods. Hence, the correlation between high-risk HPV infection and urinary system tumors remains controversial. The early open reading frame of the HPV genome is composed of E1–E7, among which E6 and E7 are the key transfer proteins. The combination of these proteins with oncogene and anti-oncogene may be one of the mechanisms leading to tumorigenesis.

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