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High-performance strategy of a simulated moving bed chromatography by simultaneous control of product and feed streams under maximum allowable pressure drop.

Authors
  • Song, Ji-Yeon1
  • Kim, Kyung-Min1
  • Lee, Chang-Ha2
  • 1 Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea, Republic of Korea. , (North Korea)
  • 2 Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea, Republic of Korea. Electronic address: [email protected] , (North Korea)
Type
Published Article
Journal
Journal of chromatography. A
Publication Date
Nov 04, 2016
Volume
1471
Pages
102–117
Identifiers
DOI: 10.1016/j.chroma.2016.10.015
PMID: 27751522
Source
Medline
Keywords
License
Unknown

Abstract

In this study, a novel operating strategy was developed to improve the separation performance of simulated moving bed (SMB) chromatography by the simultaneous control of product outlet streams and feed inlet stream (SimCon). The SimCon operation can achieve a high separation performance without exceeding the maximum allowable pressure drop in an SMB system. The SimCon operation consisted of three steps within a single switching period: the initial, middle, and last steps. The extract port and feed-inlet port were closed at the initial step, but the raffinate port was closed at the last step. Therefore, in the SimCon strategy, we introduce two additional operating variables in a switching period, namely the middle time and middle length. In the SimCon operation, the middle step is a key factor to achieving a good separation performance because concentration profiles can be well controlled by two new middle-step variables. The SimCon operation showed outstanding results compared with those of the corresponding conventional SMB and other stream-control strategies in terms of purity, recovery, productivity, and eluent consumption. Because the SimCon operation can be operated with smaller flow and pressure fluctuations than other flow-rate-control strategies and improves the column efficiency, it is expected that the strategy can be practically adapted to real SMB processes with a good separation performance.

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