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High-mobility group box 3 (HMGB3) silencing inhibits non-small cell lung cancer development through regulating Wnt/β-catenin pathway

Authors
  • Li, Yunjing1
  • Ma, Yongfu1
  • Zhang, Tong1
  • Feng, Changjiang1
  • Liu, Yang1
  • 1 PLA General Hospital, 100853 , (China)
Type
Published Article
Journal
Biological Chemistry
Publisher
Walter de Gruyter GmbH
Publication Date
Jul 16, 2020
Volume
401
Issue
10
Pages
1191–1198
Identifiers
DOI: 10.1515/hsz-2020-0144
Source
De Gruyter
Keywords
License
Yellow

Abstract

It has been reported that high-mobility group box 3 is overexpressed in various cancers. This study aimed to explore its function in non-small cell lung cancer (NSCLC). A546 and H460 cell lines were used for in vivo experiments, scratch healing tests, transwell migration and invasion experiments. It was first found that HMGB3 was highly expressed in tumor tissues in the patients and associated with NSCLC stage. Silencing of HMGB3 significantly slowed the growth, proliferation and invasion of NSCLC in vitro, and repressed cell growth in vivo. Mechanistic studies suggest that the observed effects were mediated by inhibiting the expression of β-catenin/MMP7/c-Myc in Wnt pathway. Our study highlights the role of HMGB3 in NSCLC, which may provide a therapeutic target for the treatment of NSCLC.

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