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Highly suppressible expression of single-chain interleukin-12 by doxycycline following adenoviral infection with a single-vector Tet-regulatory system.

Authors
  • Block, Andreas
  • Puls, Florian
  • Müller, Jürgen
  • Milasinovic, Dragan
  • Igelmann, Dana
  • Schäfer, Peter
  • Kupfermann, Nikolai
  • Schmoldt, Achim
  • Ameis, Detlev
  • Greten, Heiner
Type
Published Article
Journal
The journal of gene medicine
Publication Date
Mar 01, 2003
Volume
5
Issue
3
Pages
190–200
Identifiers
PMID: 12666185
Source
Medline
License
Unknown

Abstract

With expression levels exceeding those of the cytomegalovirus (CMV) promoter in almost all cell lines tested, these new vectors will also contribute to the safety of adenoviral approaches by controlled expression without compromising on maximum expression levels.

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