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A highly sensitive nucleic acid stain based on amino-modified tetraphenylethene: the influence of configuration.

Authors
  • Xu, Li1
  • Zhu, Zece
  • Zhou, Xiang
  • Qin, Jingui
  • Yang, Chuluo
  • 1 Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Department of Chemistry, Wuhan University, Wuhan, 430072, People's Republic of China. [email protected] , (China)
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
Jun 21, 2014
Volume
50
Issue
49
Pages
6494–6497
Identifiers
DOI: 10.1039/c4cc02671c
PMID: 24816690
Source
Medline
License
Unknown

Abstract

We designed and synthesized a new amino-functionalized tetraphenylethene (TPE) derivative as a highly sensitive dye for the detection of dsDNA and oligonucleotide in both solution and a gel matrix. We further revealed that the cis configuration dye showed a much higher sensitivity than its trans isomer for the first time.

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