A highly sensitive nucleic acid stain based on amino-modified tetraphenylethene: the influence of configuration.
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Department of Chemistry, Wuhan University, Wuhan, 430072, People's Republic of China. [email protected]
- Published Article
The Royal Society of Chemistry
- Publication Date
Jun 21, 2014
We designed and synthesized a new amino-functionalized tetraphenylethene (TPE) derivative as a highly sensitive dye for the detection of dsDNA and oligonucleotide in both solution and a gel matrix. We further revealed that the cis configuration dye showed a much higher sensitivity than its trans isomer for the first time.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/24816690