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Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: failure of homologous neutralizing-antibody treatment to control infection.

Authors
  • Jensen, Tanja B
  • Gottwein, Judith M
  • Scheel, Troels K H
  • Hoegh, Anne M
  • Eugen-Olsen, Jesper
  • Bukh, Jens
Type
Published Article
Journal
The Journal of infectious diseases
Publication Date
Dec 15, 2008
Volume
198
Issue
12
Pages
1756–1765
Identifiers
DOI: 10.1086/593021
PMID: 19032070
Source
Medline
License
Unknown

Abstract

The SA13/JFH1 culture permits genotype 5a-specific studies of Core-NS2 function and interfering agents. The ability of HCV to spread in vivo during treatment with neutralizing antibodies was confirmed in vitro.

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