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Highly acylated diterpenoids with a new 3,4-secograyanane skeleton from the flower buds of Rhododendron molle.

Authors
  • Wang, Sujuan
  • Lin, Sheng
  • Zhu, Chenggen
  • Yang, Yongchun
  • Li, Shuai
  • Zhang, Jianjun
  • Chen, Xiaoguang
  • Shi, Jiangong
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Apr 02, 2010
Volume
12
Issue
7
Pages
1560–1563
Identifiers
DOI: 10.1021/ol1002797
PMID: 20222684
Source
Medline
License
Unknown

Abstract

Four highly acylated diterpenoids with a new 3,4-secograyanane skeleton, secorhodomollolides A-D (1-4), have been isolated from the flower buds of Rhododendron molle. Their structures including absolute configurations were determined on the basis of spectroscopic data interpretation and single-crystal X-ray crystallography. Compound 4 exhibited significant analgesic and sedative effects at a dose of 5 mg/kg, and compound 2 showed selective cytotoxic activity against human hepatoma carcinoma cell line (Bel-7402) with IC(50) 0.97 microM.

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